NOP Receptor Agonist Ro 64-6198 Decreases Escalation of copyright Self-Administration in Rats Genetically Selected for Alcohol Preference
NOP Receptor Agonist Ro 64-6198 Decreases Escalation of copyright Self-Administration in Rats Genetically Selected for Alcohol Preference
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copyright dependence is a psychiatric condition for which effective medications are still lacking.Published data indicate that an increase in nociceptin/orphanin FQ (N/OFQ) transmission by NOP receptor activation attenuates copyright-induced place conditioning and the locomotor sensitization effects of copyright.This suggests that the activation of the N/OFQ receptor (NOP) may attenuate the motivation for psychostimulants.
To further explore this possibility, we investigated the effect of the potent and selective NOP receptor agonist Ro 64-6198 on copyright intake under 1 h short access (ShA) and 6 h long access (LgA) operant self-administration conditions in rats.We used Marchigian Sardinian alcohol-preferring (msP) rats and Wistar control rats.msP rats were used because we recently found that this rat line, originally selected for excessive alcohol drinking and preference, exhibits a greater propensity to escalate Cat Beds copyright self-administration following LgA training.
msP rats are also characterized by innate overexpression of the N/OFQ-NOP system compared with Wistar rats.Wistar and msP rats both exhibited an increase in copyright self-administration under LgA conditions, with a higher trend toward escalation in msP rats.In Wistar rats, the intraperitoneal administration Motor Cover of Ro 64-6198 (0.
1 and 3 mg/kg) significantly decreased ShA copyright self-administration.In Wistar rats that underwent LgA copyright self-administration training, Ro 64-6198 induced no significant effect either during the first hour of self-administration or after the entire 6 h session.In msP rats, Ro 64-6198 significantly reduced copyright self-administration both under ShA conditions and in the first hour of the LgA session.
At the end of the 6 h session, the effect of Ro 64-6198 was no longer observed in msP rats.The highest dose of Ro 64-6198 (3 mg/kg) did not affect saccharin self-administration in msP rats but reduced saccharin self-administration in Wistar rats.Altogether, these data suggest that NOP receptor activation attenuates copyright self-administration, and this effect tends to be more pronounced in a rat line with innately higher NOP receptor expression and that more robustly escalates copyright intake.